VTCN1

GENERAL INFORMATION

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Gene name

VTCN1

Gene description

V-set domain containing T cell activation inhibitor 1

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (fallopian tube)
GTEx:Group enriched (breast, kidney, pancreas, salivary gland)

Protein evidence

Evidence at protein level

Protein localization

Membranous and cytoplasmic expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA054200
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (fallopian tube)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (breast, kidney, pancreas, salivary gland)

Organ

Expression



GENE INFORMATION

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Gene name

VTCN1 (HGNC Symbol)

Synonyms

B7-H4, B7H4, B7S1, B7X, FLJ22418

Description

V-set domain containing T cell activation inhibitor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

1

Cytoband

Chromosome location (bp)

117143587 - 117210960

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134258 (version 78.38)

Entrez gene

79679

UniProt

Q7Z7D3 (UniProt - Evidence at protein level)

neXtProt

NX_Q7Z7D3

Antibodypedia

VTCN1 antibodies


PROTEIN BROWSER

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ENST00000328189
 
ENST00000359008
 
ENST00000369458
 
ENST00000430871
 
ENST00000539893
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VTCN1-001 ENSP00000358470
ENST00000369458
Q7Z7D3
Show all »
Show » Show » 282 30.9 No 2
VTCN1-002 ENSP00000351899
ENST00000359008
Q5T2L0
Show all »
Show » Show » 285 31.3 No 2
VTCN1-201 ENSP00000328168
ENST00000328189
Q7Z7D3
Show all »
Show » Show » 166 18.3 No 2
VTCN1-202 ENSP00000484316
ENST00000430871
Show » 87 9.8 No 1
VTCN1-203 ENSP00000444724
ENST00000539893
Q7Z7D3
Show all »
Show » Show » 187 20.7 No 0