FBXO18

GENE INFORMATION

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Gene name

FBXO18 (HGNC Symbol)

Synonyms

FBH1, Fbx18, FLJ14590

Description

F-box protein, helicase, 18 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

p15.1

Chromosome location (bp)

5931535 - 5979556

Ensembl

ENSG00000134452 (version 73.37)

Entrez gene

84893

UniProt

Q8NFZ0 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NFZ0

Antibodypedia

FBXO18 antibodies
 

PROTEIN VIEW

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FBXO18-009
 
FBXO18-010
 
FBXO18-011
 
FBXO18-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FBXO18-009 ENSP00000355415
ENST00000362091
Q8NFZ0
Show all »
Show » Show » 1043 117.7 No 1
FBXO18-010 ENSP00000369335
ENST00000379999
Q8NFZ0
Show all »
Show » Show » 1094 123.4 No 1
FBXO18-011 ENSP00000369330
ENST00000379994
Q5JVB6
Show all »
Show » Show » 404 45.5 No 1
FBXO18-201 ENSP00000380439
ENST00000397269
B3KV95
Show all »
Show » 547 62 No 0