IL2RA

GENE INFORMATION

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Gene name

IL2RA (HGNC Symbol)

Synonyms

CD25, IL2R

Description

interleukin 2 receptor, alpha (HGNC Symbol)

Entrez gene summary

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

Chromosome

10 (Chromosome progress)

Cytoband

p15.1

Chromosome location (bp)

6052652 - 6104288

Ensembl

ENSG00000134460 (version 73.37)

Entrez gene

3559

UniProt

P01589 (UniProt - Evidence at protein level)

neXtProt

NX_P01589

Antibodypedia

IL2RA antibodies
 

PROTEIN VIEW

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IL2RA-001
 
IL2RA-002
 
IL2RA-004
 
IL2RA-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL2RA-001 ENSP00000369293
ENST00000379959
P01589
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Show » Show » 272 30.8 Yes 1
IL2RA-002 ENSP00000369287
ENST00000379954
Q5W005
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Show » 200 22.5 Yes 1
IL2RA-004 ENSP00000256876
ENST00000256876
Q5W006
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Show » 263 29.8 Yes 1
IL2RA-005 ENSP00000402024
ENST00000447847
O15163
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109 12.2 No 0