IL15RA

GENERAL INFORMATION

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Gene name

IL15RA

Gene description

Interleukin 15 receptor, alpha

Protein class

CD markers
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

19
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

The intestine tract, megakaryocytes, decidual cells and subsets of cells in salivary gland displayed strong cytoplasmic staining. The remaining normal tissues generally showed moderate cytoplasmic positivity. Additional membranous positivity was observed in gall bladder, trophoblasts and uterine glands. Endothelial cells generally showed distinct immunoreactivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB026215
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

IL15RA (HGNC Symbol)

Synonyms

CD215, IL-15RA

Description

Interleukin 15 receptor, alpha (HGNC Symbol)

Entrez gene summary

This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]

Chromosome

10

Cytoband

p15.1

Chromosome location (bp)

5937569 - 5978187

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134470 (version 78.38)

Entrez gene

3601

UniProt

Q13261 (UniProt - Evidence at protein level)

neXtProt

NX_Q13261

Antibodypedia

IL15RA antibodies


PROTEIN BROWSER

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ENST00000379971
 
ENST00000379977
 
ENST00000397246
 
ENST00000397248
 
ENST00000397250
 
ENST00000397251
 
ENST00000397255
 
ENST00000429135
 
ENST00000435171
 
ENST00000447291
 
ENST00000453922
 
ENST00000525219
 
ENST00000528354
 
ENST00000530685
 
ENST00000532039
 
ENST00000618528
 
ENST00000620345
 
ENST00000620865
 
ENST00000622442
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL15RA-001 ENSP00000369312
ENST00000379977
Q13261
Show all »
Show » Show » 267 28.2 Yes 1
IL15RA-005 ENSP00000369306
ENST00000379971
Q13261
Show all »
Show » Show » 154 15.7 Yes 1
IL15RA-006 ENSP00000435454
ENST00000528354
Q13261
Show all »
Show » Show » 234 24.9 Yes 1
IL15RA-007 ENSP00000405107
ENST00000453922
Q5JVA3
Show all »
Show » 148 15.6 No 0
IL15RA-008 ENSP00000405128
ENST00000447291
Show » 155 15.5 No 1
IL15RA-009 ENSP00000393612
ENST00000435171
Show » 198 21.1 No 1
IL15RA-011 ENSP00000432691
ENST00000532039
Show » 209 23 No 1
IL15RA-012 ENSP00000380422
ENST00000397250
Q13261
Show all »
Show » Show » 169 17.6 Yes 1
IL15RA-013 ENSP00000395113
ENST00000429135
E9PQ64
Show all »
Show » 172 18.3 Yes 0
IL15RA-014 ENSP00000435995
ENST00000530685
Q13261
Show all »
Show » Show » 219 22.9 Yes 1
IL15RA-016 ENSP00000380426
ENST00000397255
Q13261
Show all »
Show » Show » 252 26.3 Yes 1
IL15RA-019 ENSP00000380420
ENST00000397246
E7ETI1
Show all »
Show » 172 18.1 No 1
IL15RA-201 ENSP00000380421
ENST00000397248
G8CVM3
Show all »
Show » Show » 353 37.6 No 1
IL15RA-202 ENSP00000380423
ENST00000397251
K9N1J3
Show all »
Show » 308 32.8 Yes 1
IL15RA-203 ENSP00000431529
ENST00000525219
Q13261
Show all »
Show » Show » 231 24.4 No 1
IL15RA-204 ENSP00000479938
ENST00000618528
K9N0C7
Show all »
Show » 316 33.8 Yes 1
IL15RA-205 ENSP00000479839
ENST00000620345
K9N163
Show all »
Show » 331 35.4 Yes 1
IL15RA-206 ENSP00000478525
ENST00000620865
K9N2S2
Show all »
Show » 305 33.4 Yes 1
IL15RA-207 ENSP00000480949
ENST00000622442
K9N2Q6
Show all »
Show » 346 37.2 Yes 1