MYBPC3

GENE INFORMATION

? »

Gene name

MYBPC3 (HGNC Symbol)

Synonyms

CMH4, FHC, MYBP-C

Description

myosin binding protein C, cardiac (HGNC Symbol)

Entrez gene summary

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

p11.2

Chromosome location (bp)

47352957 - 47374253

Ensembl

ENSG00000134571 (version 73.37)

Entrez gene

4607

UniProt

Q14896 (UniProt - Evidence at protein level)

neXtProt

NX_Q14896

Antibodypedia

MYBPC3 antibodies
 

PROTEIN VIEW

? »
 
 
 
MYBPC3-001
 
MYBPC3-004
 
MYBPC3-201
 
MYBPC3-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYBPC3-001 ENSP00000442795
ENST00000545968
Q14896
Show all »
Show » 1274 140.8 No 0
MYBPC3-004 ENSP00000444259
ENST00000544791
F5GZR4
Show all »
Show » 808 88.1 No 0
MYBPC3-201 ENSP00000256993
ENST00000256993
Q14896
Show all »
Show » 1273 140.6 No 0
MYBPC3-202 ENSP00000382193
ENST00000399249
A8MXZ9
Show all »
Show » 1274 140.7 No 0