DDB2

GENE INFORMATION

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Gene name

DDB2 (HGNC Symbol)

Synonyms

DDBB, FLJ34321, UV-DDB2

Description

damage-specific DNA binding protein 2, 48kDa (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

p11.2

Chromosome location (bp)

47236493 - 47260767

Ensembl

ENSG00000134574 (version 73.37)

Entrez gene

1643

UniProt

Q92466 (UniProt - Evidence at protein level)

neXtProt

NX_Q92466

Antibodypedia

DDB2 antibodies
 

PROTEIN VIEW

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DDB2-201
 
DDB2-202
 
DDB2-203
 
DDB2-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DDB2-201 ENSP00000256996
ENST00000256996
Q92466
Show all »
Show » Show » 427 47.9 No 0
DDB2-202 ENSP00000367863
ENST00000378600
Q92466
Show all »
Show » Show » 238 26.7 No 0
DDB2-203 ENSP00000367864
ENST00000378601
Q92466
Show all »
Show » Show » 244 26.8 No 0
DDB2-204 ENSP00000367866
ENST00000378603
Q92466
Show all »
Show » Show » 363 40.8 No 0