PDGFRA

GENE INFORMATION

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Gene name

PDGFRA (HGNC Symbol)

Synonyms

CD140a, PDGFR2

Description

platelet-derived growth factor receptor, alpha polypeptide (HGNC Symbol)

Entrez gene summary

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]

Chromosome

4 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

55095264 - 55164414

Ensembl

ENSG00000134853 (version 73.37)

Entrez gene

5156

UniProt

P16234 (UniProt - Evidence at protein level)

neXtProt

NX_P16234

Antibodypedia

PDGFRA antibodies
 

PROTEIN VIEW

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PDGFRA-001
 
PDGFRA-002
 
PDGFRA-006
 
PDGFRA-007
 
PDGFRA-008
 
PDGFRA-009
 
PDGFRA-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDGFRA-001 ENSP00000257290
ENST00000257290
P16234
Show all »
Show » Show » 1089 122.7 Yes 1
PDGFRA-002 ENSP00000425648
ENST00000508170
P16234
Show all »
Show » Show » 218 24 Yes 0
PDGFRA-006 ENSP00000426472
ENST00000504461
D6RG11
Show all »
Show » Show » 158 17.5 Yes 0
PDGFRA-007 ENSP00000425902
ENST00000503856
D6RIG5
Show all »
Show » Show » 159 17.6 Yes 0
PDGFRA-008 ENSP00000424218
ENST00000509490
P16234
Show all »
Show » Show » 743 82.8 Yes 1
PDGFRA-009 ENSP00000425626
ENST00000512143
D6RJH0
Show all »
Show » Show » 147 16.5 No 0
PDGFRA-010 ENSP00000425232
ENST00000512522
D6RDX0
Show all »
Show » Show » 154 17.1 Yes 0