ADAMTS8

GENE INFORMATION

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Gene name

ADAMTS8 (HGNC Symbol)

Synonyms

ADAM-TS8, FLJ41712, METH2

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q24.3

Chromosome location (bp)

130274820 - 130298888

Ensembl

ENSG00000134917 (version 73.37)

Entrez gene

11095

UniProt

Q9UP79 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9UP79

Antibodypedia

ADAMTS8 antibodies
 

PROTEIN VIEW

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ADAMTS8-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS8-001 ENSP00000257359
ENST00000257359
Q9UP79
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