APC

GENE INFORMATION

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Gene name

APC (HGNC Symbol)

Synonyms

DP2, DP2.5, DP3, PPP1R46

Description

adenomatous polyposis coli (HGNC Symbol)

Entrez gene summary

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q22.2

Chromosome location (bp)

112043195 - 112181936

Ensembl

ENSG00000134982 (version 73.37)

Entrez gene

324

UniProt

P25054 (UniProt - Evidence at protein level)

neXtProt

NX_P25054

Antibodypedia

APC antibodies
 

PROTEIN VIEW

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APC-001
 
APC-002
 
APC-003
 
APC-004
 
APC-005
 
APC-008
 
APC-011
 
APC-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APC-001 ENSP00000257430
ENST00000257430
P25054
Show all »
Show » Show » 2843 311.6 No 0
APC-002 ENSP00000423224
ENST00000507379
B7Z2B6
Show all »
Show » Show » 1135 126.2 No 0
APC-003 ENSP00000424265
ENST00000508624
E7EMH9
Show all »
Show » Show » 287 32.8 No 0
APC-004 ENSP00000427089
ENST00000508376
P25054
Show all »
Show » Show » 2843 311.6 No 0
APC-005 ENSP00000423828
ENST00000512211
E9PFT7
Show all »
Show » Show » 1305 145.8 No 0
APC-008 ENSP00000426541
ENST00000509732
D6RFL6
Show all »
Show » Show » 118 13 No 0
APC-011 ENSP00000473355
ENST00000504915
R4GMU6
Show all »
Show » Show » 272 29.7 No 0
APC-201 ENSP00000413133
ENST00000457016
P25054
Show all »
Show » Show » 2843 311.6 No 0