CTSL

GENE INFORMATION

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Gene name

CTSL (HGNC Symbol)

Synonyms

CTSL1, FLJ31037

Description

cathepsin L (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

9 (Chromosome progress)

Cytoband

q21.33

Chromosome location (bp)

90340434 - 90346308

Ensembl

ENSG00000135047 (version 73.37)

Entrez gene

1514

UniProt

P07711 (UniProt - Evidence at protein level)

neXtProt

NX_P07711

Antibodypedia

CTSL antibodies
 

PROTEIN VIEW

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CTSL-001
 
CTSL-002
 
CTSL-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSL-001 ENSP00000345344
ENST00000343150
P07711
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Show » Show » 333 37.6 Yes 0
CTSL-002 ENSP00000365061
ENST00000340342
P07711
Show all »
Show » Show » 333 37.6 Yes 0
CTSL-004 ENSP00000340470
ENST00000342020
Q5T8F0
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Show » Show » 225 25.5 Yes 0