MAP3K7

GENE INFORMATION

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Gene name

MAP3K7 (HGNC Symbol)

Synonyms

MEKK7, TAK1

Description

mitogen-activated protein kinase kinase kinase 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

q15

Chromosome location (bp)

91223292 - 91296764

Ensembl

ENSG00000135341 (version 73.37)

Entrez gene

6885

UniProt

O43318 (UniProt - Evidence at protein level)

neXtProt

NX_O43318

Antibodypedia

MAP3K7 antibodies
 

PROTEIN VIEW

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MAP3K7-001
 
MAP3K7-002
 
MAP3K7-003
 
MAP3K7-004
 
MAP3K7-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K7-001 ENSP00000358338
ENST00000369332
O43318
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Show » Show » 579 64.2 No 0
MAP3K7-002 ENSP00000358335
ENST00000369329
O43318
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Show » Show » 606 67.2 No 0
MAP3K7-003 ENSP00000358331
ENST00000369325
O43318
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Show » Show » 518 56.7 No 0
MAP3K7-004 ENSP00000358333
ENST00000369327
O43318
Show all »
Show » Show » 491 53.7 No 0
MAP3K7-006 ENSP00000358326
ENST00000369320
Q9UG54
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260 28.9 No 0