PHF21A

GENERAL INFORMATION

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Gene name

PHF21A

Gene description

PHD finger protein 21A

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal cells displayed moderate cytoplasmic staining combined with additional nucleolar positivity in some cases. Smooth muscle, megakaryocytes and myoepithelium showed strong cytoplasmic staining. Trophoblasts, prostate and the large intestine showed additional membranous positivity. Lymphoid tissue were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA023580
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PHF21A (HGNC Symbol)

Synonyms

BHC80, BM-006, KIAA1696

Description

PHD finger protein 21A (HGNC Symbol)

Entrez gene summary

The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]

Chromosome

11

Cytoband

p11.2

Chromosome location (bp)

45929323 - 46121178

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135365 (version 78.38)

Entrez gene

51317

UniProt

Q96BD5 (UniProt - Evidence at protein level)

neXtProt

NX_Q96BD5

Antibodypedia

PHF21A antibodies


PROTEIN BROWSER

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ENST00000323180
 
ENST00000418153
 
ENST00000524497
 
ENST00000525438
 
ENST00000525676
 
ENST00000527782
 
ENST00000529734
 
ENST00000529782
 
ENST00000531959
 
ENST00000532010
 
ENST00000532028
 
ENST00000533757
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHF21A-002 ENSP00000323152
ENST00000323180
Q96BD5
Show all »
Show » Show » 634 70.2 No 0
PHF21A-004 ENSP00000398824
ENST00000418153
Q96BD5
Show all »
Show » Show » 680 74.9 No 0
PHF21A-007 ENSP00000436157
ENST00000529734
E9PQM3
Show all »
Show » 101 11.9 No 0
PHF21A-008 ENSP00000434687
ENST00000527782
Show » 11 1.3 No 0
PHF21A-009 ENSP00000432406
ENST00000533757
E9PR02
Show all »
Show » 51 5.9 No 0
PHF21A-010 ENSP00000437110
ENST00000525438
E9PNW9
Show all »
Show » 26 3.1 No 0
PHF21A-011 ENSP00000435121
ENST00000529782
E9PLV4
Show all »
Show » 63 7.4 No 0
PHF21A-016 ENSP00000431964
ENST00000525676
Show » 93 10.3 No 0
PHF21A-018 ENSP00000431621
ENST00000532028
H0YCI1
Show all »
Show » 150 16.4 No 0
PHF21A-019 ENSP00000435645
ENST00000532010
Show » 9 1.1 No 0
PHF21A-020 ENSP00000432916
ENST00000531959
E9PLU5
Show all »
Show » 134 15.4 No 0
PHF21A-021 ENSP00000431273
ENST00000524497
E9PLU5
Show all »
Show » 134 15.4 No 0