CDK4

GENE INFORMATION

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Gene name

CDK4 (HGNC Symbol)

Synonyms

PSK-J3

Description

cyclin-dependent kinase 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

q14.1

Chromosome location (bp)

58141510 - 58149796

Ensembl

ENSG00000135446 (version 73.37)

Entrez gene

1019

UniProt

P11802 (UniProt - Evidence at protein level)

neXtProt

NX_P11802

Antibodypedia

CDK4 antibodies
 

PROTEIN VIEW

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 « 
 
CDK4-001
 
CDK4-003
 
CDK4-004
 
CDK4-005
 
CDK4-006
 
CDK4-007
 
CDK4-008
 
CDK4-009
 
CDK4-010
 
CDK4-011
 
CDK4-012
 
CDK4-201
 
CDK4-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK4-001 ENSP00000257904
ENST00000257904
P11802
Show all »
Show » Show » 303 33.7 No 0
CDK4-003 ENSP00000448885
ENST00000553237
F8VYY1
Show all »
Show » Show » 74 7.8 No 0
CDK4-004 ENSP00000447005
ENST00000549606
F8VZ13
Show all »
Show » Show » 40 4.6 No 0
CDK4-005 ENSP00000449391
ENST00000551800
F8VXD2
Show all »
Show » Show » 132 14.9 No 0
CDK4-006 ENSP00000448963
ENST00000552388
F8VYH9
Show all »
Show » Show » 170 18.7 No 0
CDK4-007 ENSP00000447779
ENST00000546489
F8VZ51
Show all »
Show » Show » 208 23.5 No 0
CDK4-008 ENSP00000448098
ENST00000550419
F8VTV8
Show all »
Show » Show » 201 22 No 0
CDK4-009 ENSP00000447274
ENST00000547281
F8VZZ0
Show all »
Show » Show » 186 21 No 0
CDK4-010 ENSP00000449725
ENST00000547853
Show » 2 0.2 No 0
CDK4-011 ENSP00000449179
ENST00000552254
F8VWX7
Show all »
Show » Show » 203 22.4 No 0
CDK4-012 ENSP00000446763
ENST00000552862
F8W1L8
Show all »
Show » Show » 115 12.5 No 0
CDK4-201 ENSP00000316889
ENST00000312990
Q96BE9
Show all »
Show » Show » 111 12 No 0
CDK4-202 ENSP00000439076
ENST00000540325
B4DNF9
Show all »
Show » Show » 183 20.7 No 0