ESPL1

GENE INFORMATION

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Gene name

ESPL1 (HGNC Symbol)

Synonyms

ESP1, KIAA0165, SEPA

Description

extra spindle pole bodies homolog 1 (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]

Chromosome

12 (Chromosome progress)

Cytoband

q13.13

Chromosome location (bp)

53662083 - 53687427

Ensembl

ENSG00000135476 (version 73.37)

Entrez gene

9700

UniProt

Q14674 (UniProt - Evidence at protein level)

neXtProt

NX_Q14674

Antibodypedia

ESPL1 antibodies
 

PROTEIN VIEW

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ESPL1-001
 
ESPL1-002
 
ESPL1-007
 
ESPL1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ESPL1-001 ENSP00000447054
ENST00000552671
H3BM31
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49 5.5 No 0
ESPL1-002 ENSP00000449831
ENST00000552462
Q14674
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Show » Show » 2120 233.2 No 1
ESPL1-007 ENSP00000456450
ENST00000553219
H3BRX7
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Show » 207 22.6 No 0
ESPL1-201 ENSP00000257934
ENST00000257934
Q14674
Show all »
Show » Show » 2120 233.2 No 1