ACVR1B

GENE INFORMATION

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Gene name

ACVR1B (HGNC Symbol)

Synonyms

ActRIB, ACVRLK4, ALK4, SKR2

Description

activin A receptor, type IB (HGNC Symbol)

Entrez gene summary

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Chromosome

12 (Chromosome progress)

Cytoband

q13.13

Chromosome location (bp)

52345451 - 52390862

Ensembl

ENSG00000135503 (version 73.37)

Entrez gene

91

UniProt

P36896 (UniProt - Evidence at protein level)

neXtProt

NX_P36896

Antibodypedia

ACVR1B antibodies
 

PROTEIN VIEW

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ACVR1B-001
 
ACVR1B-002
 
ACVR1B-003
 
ACVR1B-004
 
ACVR1B-005
 
ACVR1B-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACVR1B-001 ENSP00000442885
ENST00000542485
P36896
Show all »
Show » Show » 453 51.7 No 1
ACVR1B-002 ENSP00000257963
ENST00000257963
P36896
Show all »
Show » Show » 505 56.8 Yes 1
ACVR1B-003 ENSP00000397550
ENST00000415850
P36896
Show all »
Show » Show » 487 54.3 Yes 1
ACVR1B-004 ENSP00000442656
ENST00000541224
P36896
Show all »
Show » Show » 546 61.4 Yes 1
ACVR1B-005 ENSP00000390477
ENST00000426655
P36896
Show all »
Show » Show » 476 53.4 Yes 1
ACVR1B-006 ENSP00000443218
ENST00000536420
F5H5Q2
Show all »
Show » 71 8.2 No 0