AGT

GENE INFORMATION

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Gene name

AGT (HGNC Symbol)

Synonyms

SERPINA8

Description

angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q42.2

Chromosome location (bp)

230838269 - 230850043

Ensembl

ENSG00000135744 (version 73.37)

Entrez gene

183

UniProt

P01019 (UniProt - Evidence at protein level)

neXtProt

NX_P01019

Antibodypedia

AGT antibodies
 

PROTEIN VIEW

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AGT-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AGT-001 ENSP00000355627
ENST00000366667
P01019
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