CAPN9

GENE INFORMATION

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Gene name

CAPN9 (HGNC Symbol)

Synonyms

GC36, nCL-4

Description

calpain 9 (HGNC Symbol)

Entrez gene summary

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q42.2

Chromosome location (bp)

230883130 - 230937749

Ensembl

ENSG00000135773 (version 73.37)

Entrez gene

10753

UniProt

O14815 (UniProt - Evidence at protein level)

neXtProt

NX_O14815

Antibodypedia

CAPN9 antibodies
 

PROTEIN VIEW

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CAPN9-001
 
CAPN9-002
 
CAPN9-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAPN9-001 ENSP00000271971
ENST00000271971
O14815
Show all »
Show » Show » 690 79.1 No 0
CAPN9-002 ENSP00000346538
ENST00000354537
O14815
Show all »
Show » Show » 664 76.2 No 0
CAPN9-201 ENSP00000355626
ENST00000366666
E7ESS6
Show all »
Show » 627 72.3 No 0