GLUL

GENERAL INFORMATION

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Gene name

GLUL

Gene description

Glutamate-ammonia ligase

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several different cell types. Very distinct expression in e.g hepatocytes around the central vein and astrocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA007316 , HPA007571 , CAB008636
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

GLUL (HGNC Symbol)

Synonyms

GLNS

Description

Glutamate-ammonia ligase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

1

Cytoband

q25.3

Chromosome location (bp)

182381704 - 182392206

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135821 (version 78.38)

Entrez gene

2752

UniProt

P15104 (UniProt - Evidence at protein level)

neXtProt

NX_P15104

Antibodypedia

GLUL antibodies


PROTEIN BROWSER

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ENST00000311223
 
ENST00000331872
 
ENST00000339526
 
ENST00000417584
 
ENST00000621524
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLUL-001 ENSP00000356537
ENST00000331872
P15104
Show all »
Show » Show » 373 42.1 No 0
GLUL-002 ENSP00000344958
ENST00000339526
P15104
Show all »
Show » Show » 373 42.1 No 0
GLUL-201 ENSP00000307900
ENST00000311223
P15104
Show all »
Show » Show » 373 42.1 No 0
GLUL-202 ENSP00000398320
ENST00000417584
P15104
Show all »
Show » Show » 373 42.1 No 0
GLUL-203 ENSP00000481855
ENST00000621524
Show » Show » 233 26.4 No 0