NEK3

GENE INFORMATION

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Gene name

NEK3 (HGNC Symbol)

Synonyms

HSPK36, MGC29949

Description

NIMA-related kinase 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Chromosome

13 (Chromosome progress)

Cytoband

q14.3

Chromosome location (bp)

52706775 - 52733996

Ensembl

ENSG00000136098 (version 73.37)

Entrez gene

4752

UniProt

P51956 (UniProt - Evidence at protein level)

neXtProt

NX_P51956

Antibodypedia

NEK3 antibodies
 

PROTEIN VIEW

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NEK3-001
 
NEK3-002
 
NEK3-003
 
NEK3-005
 
NEK3-006
 
NEK3-008
 
NEK3-201
 
NEK3-202
 
NEK3-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NEK3-001 ENSP00000449608
ENST00000548127
G3V202
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Show » Show » 299 34.4 No 0
NEK3-002 ENSP00000383210
ENST00000400357
P51956
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Show » Show » 489 55.9 No 0
NEK3-003 ENSP00000448782
ENST00000258597
G3V202
Show all »
Show » Show » 299 34.4 No 0
NEK3-005 ENSP00000449679
ENST00000550841
F8VV00
Show all »
Show » 58 6.7 No 0
NEK3-006 ENSP00000447995
ENST00000551355
F8VTT4
Show all »
Show » 46 5.3 No 0
NEK3-008 ENSP00000449055
ENST00000547820
29 3.2 No 0
NEK3-201 ENSP00000339429
ENST00000339406
J3KPF4
Show all »
Show » Show » 506 57.7 No 0
NEK3-202 ENSP00000367341
ENST00000378101
J3KPF4
Show all »
Show » Show » 506 57.7 No 0
NEK3-203 ENSP00000404197
ENST00000452082
Q6ZN64
Show all »
Show » Show » 510 58 No 0