RNASEH2B

GENE INFORMATION

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Gene name

RNASEH2B (HGNC Symbol)

Synonyms

AGS2, DLEU8, FLJ11712

Description

ribonuclease H2, subunit B (HGNC Symbol)

Entrez gene summary

RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]

Chromosome

13 (Chromosome progress)

Cytoband

q14.3

Chromosome location (bp)

51483814 - 51544592

Ensembl

ENSG00000136104 (version 73.37)

Entrez gene

79621

UniProt

Q5TBB1 (UniProt - Evidence at protein level)

neXtProt

NX_Q5TBB1

Antibodypedia

RNASEH2B antibodies
 

PROTEIN VIEW

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RNASEH2B-001
 
RNASEH2B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RNASEH2B-001 ENSP00000337623
ENST00000336617
Q5TBB1
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Show » 312 35.1 No 0
RNASEH2B-201 ENSP00000389877
ENST00000422660
G3XAJ1
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Show » 257 29 No 0