ITM2B

GENE INFORMATION

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Gene name

ITM2B (HGNC Symbol)

Synonyms

BRI, BRICD2B, E25B, E3-16

Description

Integral membrane protein 2B (HGNC Symbol)

Entrez gene summary

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]

Chromosome

13

Cytoband

q14.2

Chromosome location (bp)

48807294 - 48837063

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136156 (version 75.37)

Entrez gene

9445

UniProt

Q9Y287 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y287

Antibodypedia

ITM2B antibodies
 

PROTEIN VIEW

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ITM2B-001
 
ITM2B-002
 
ITM2B-003
 
ITM2B-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITM2B-001 ENSP00000367828
ENST00000378565
Q9Y287
Show all »
Show » Show » 266 30.3 No 1
ITM2B-002 ENSP00000476004
ENST00000463839
Show » 29 3.2 No 0
ITM2B-003 ENSP00000367811
ENST00000378549
Q5W0A2
Show all »
Show » 160 18.3 No 1
ITM2B-004 ENSP00000475556
ENST00000607866
Show » 53 5.7 No 0