EDNRB

GENE INFORMATION

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Gene name

EDNRB (HGNC Symbol)

Synonyms

ETB, HSCR, HSCR2

Description

endothelin receptor type B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Chromosome

13 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

78469616 - 78493903

Ensembl

ENSG00000136160 (version 73.37)

Entrez gene

1910

UniProt

P24530 (UniProt - Evidence at protein level)

neXtProt

NX_P24530

Antibodypedia

EDNRB antibodies
 

PROTEIN VIEW

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EDNRB-001
 
EDNRB-003
 
EDNRB-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EDNRB-001 ENSP00000366416
ENST00000377211
P24530
Show all »
Show » Show » 532 59.5 No 8
EDNRB-003 ENSP00000335311
ENST00000334286
P24530
Show all »
Show » Show » 442 49.6 Yes 7
EDNRB-201 ENSP00000403401
ENST00000446573
P24530
Show all »
Show » Show » 436 48.7 Yes 7