KDELR2

GENERAL INFORMATION

? »

Gene name

KDELR2

Gene description

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 2 antibodies.
HPA016459 , HPA047440
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

KDELR2 (HGNC Symbol)

Synonyms

ELP-1, ERD2.2

Description

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 (HGNC Symbol)

Entrez gene summary

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p22.1

Chromosome location (bp)

6445953 - 6484242

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136240 (version 78.38)

Entrez gene

11014

UniProt

P33947 (UniProt - Evidence at protein level)

neXtProt

NX_P33947

Antibodypedia

KDELR2 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000258739
 
ENST00000490996
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KDELR2-001 ENSP00000258739
ENST00000258739
P33947
Show all »
Show » Show » 212 24.4 No 7
KDELR2-006 ENSP00000420501
ENST00000490996
P33947
Show all »
Show » Show » 186 21.2 No 5