IL6

GENE INFORMATION

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Gene name

IL6 (HGNC Symbol)

Synonyms

BSF2, HGF, HSF, IFNB2, IL-6

Description

interleukin 6 (interferon, beta 2) (HGNC Symbol)

Entrez gene summary

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]

Chromosome

7 (Chromosome progress)

Cytoband

p15.3

Chromosome location (bp)

22765503 - 22771621

Ensembl

ENSG00000136244 (version 73.37)

Entrez gene

3569

UniProt

P05231 (UniProt - Evidence at protein level)

neXtProt

NX_P05231

Antibodypedia

IL6 antibodies
 

PROTEIN VIEW

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IL6-001
 
IL6-002
 
IL6-003
 
IL6-004
 
IL6-005
 
IL6-006
 
IL6-201
 
IL6-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL6-001 ENSP00000385675
ENST00000404625
P05231
Show all »
Show » Show » 212 23.7 Yes 0
IL6-002 ENSP00000405150
ENST00000426291
C9J5B0
Show all »
Show » Show » 152 16.8 Yes 0
IL6-003 ENSP00000385718
ENST00000401651
B4DNV3
Show all »
Show » 122 13.9 No 0
IL6-004 ENSP00000385043
ENST00000407492
B5MC21
Show all »
Show » 136 15.6 No 0
IL6-005 ENSP00000384928
ENST00000401630
B5MCZ3
Show all »
Show » 189 21.5 No 0
IL6-006 ENSP00000385227
ENST00000406575
B5MC14
Show all »
Show » Show » 198 22.1 Yes 0
IL6-201 ENSP00000258743
ENST00000258743
P05231
Show all »
Show » Show » 212 23.7 Yes 0
IL6-202 ENSP00000405994
ENST00000420258
B4DNQ5
Show all »
Show » Show » 252 27.5 No 1