SCN7A

GENE INFORMATION

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Gene name

SCN7A (HGNC Symbol)

Synonyms

NaG, Nav2.1, Nav2.2, SCN6A

Description

sodium channel, voltage-gated, type VII, alpha subunit (HGNC Symbol)

Entrez gene summary

This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]

Chromosome

2 (Chromosome progress)

Cytoband

q24.3

Chromosome location (bp)

167260083 - 167350757

Ensembl

ENSG00000136546 (version 73.37)

Entrez gene

6332

UniProt

Q01118 (UniProt - Evidence at transcript level)

neXtProt

NX_Q01118

Antibodypedia

SCN7A antibodies
 

PROTEIN VIEW

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SCN7A-001
 
SCN7A-002
 
SCN7A-003
 
SCN7A-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SCN7A-001 ENSP00000386796
ENST00000409855
Q01118
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Show » Show » 1682 193.5 No >9
SCN7A-002 ENSP00000413699
ENST00000419992
C9JW43
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Show » Show » 863 99.4 No 9
SCN7A-003 ENSP00000396600
ENST00000424326
F8WD82
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Show » Show » 762 88.1 No 9
SCN7A-004 ENSP00000403846
ENST00000441411
C9JII9
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Show » Show » 402 46.4 No 5