IL10

GENERAL INFORMATION

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Gene name

IL10

Gene description

Interleukin 10

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (adipose tissue, spleen)

Protein evidence

Evidence at protein level

Protein localization

Strong cytoplasmic positivity was observed in pancreatic islet cells, neuronal cells of cerebral cortex, epididymis, seminal vesicle and cervical glands. Strong membranous positivity was observed in breast. Subsets of cells in seminiferus ducts displayed strong nuclear staining. The majority of remaining tissues showed weak to moderate cytoplasmic positivity. Lymphoid tissues and glandular cells in the intestine were mainly negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB013120
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (adipose tissue, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

IL10 (HGNC Symbol)

Synonyms

CSIF, IL-10, IL10A, TGIF

Description

Interleukin 10 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

206767602 - 206772494

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136634 (version 78.38)

Entrez gene

3586

UniProt

P22301 (UniProt - Evidence at protein level)

neXtProt

NX_P22301

Antibodypedia

IL10 antibodies


PROTEIN BROWSER

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ENST00000423557
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL10-001 ENSP00000412237
ENST00000423557
P22301
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