IL1RN

GENE INFORMATION

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Gene name

IL1RN (HGNC Symbol)

Synonyms

ICIL-1RA, IL-1RN, IL1F3, IL1RA, IRAP, MGC10430

Description

interleukin 1 receptor antagonist (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q13

Chromosome location (bp)

113864791 - 113891593

Ensembl

ENSG00000136689 (version 73.37)

Entrez gene

3557

UniProt

P18510 (UniProt - Evidence at protein level)

neXtProt

NX_P18510

Antibodypedia

IL1RN antibodies
 

PROTEIN VIEW

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IL1RN-001
 
IL1RN-002
 
IL1RN-003
 
IL1RN-004
 
IL1RN-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL1RN-001 ENSP00000259206
ENST00000259206
P18510
Show all »
Show » Show » 180 19.9 No 0
IL1RN-002 ENSP00000329072
ENST00000354115
P18510
Show all »
Show » Show » 159 17.9 No 0
IL1RN-003 ENSP00000354816
ENST00000361779
P18510
Show all »
Show » Show » 143 16.1 No 0
IL1RN-004 ENSP00000387210
ENST00000409052
P18510
Show all »
Show » Show » 143 16.1 No 0
IL1RN-005 ENSP00000387173
ENST00000409930
P18510
Show all »
Show » Show » 177 20.1 Yes 0