BIN1

GENE INFORMATION

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Gene name

BIN1 (HGNC Symbol)

Synonyms

AMPH2, AMPHL, SH3P9

Description

bridging integrator 1 (HGNC Symbol)

Entrez gene summary

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011]

Chromosome

2 (Chromosome progress)

Cytoband

q14.3

Chromosome location (bp)

127805603 - 127864931

Ensembl

ENSG00000136717 (version 73.37)

Entrez gene

274

UniProt

O00499 (UniProt - Evidence at protein level)

neXtProt

NX_O00499

Antibodypedia

BIN1 antibodies
 

PROTEIN VIEW

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 « 
 
BIN1-001
 
BIN1-002
 
BIN1-003
 
BIN1-004
 
BIN1-005
 
BIN1-006
 
BIN1-007
 
BIN1-008
 
BIN1-010
 
BIN1-011
 
BIN1-012
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BIN1-001 ENSP00000316779
ENST00000316724
O00499
Show all »
Show » Show » 593 64.7 No 0
BIN1-002 ENSP00000350654
ENST00000357970
O00499
Show all »
Show » Show » 550 59.9 No 0
BIN1-003 ENSP00000315388
ENST00000351659
O00499
Show all »
Show » Show » 506 55.2 No 0
BIN1-004 ENSP00000259238
ENST00000259238
O00499
Show all »
Show » Show » 497 54.9 No 0
BIN1-005 ENSP00000315411
ENST00000346226
O00499
Show all »
Show » Show » 518 56.5 No 0
BIN1-006 ENSP00000376760
ENST00000393040
O00499
Show all »
Show » Show » 482 53 No 0
BIN1-007 ENSP00000376761
ENST00000393041
O00499
Show all »
Show » Show » 475 51.7 No 0
BIN1-008 ENSP00000315284
ENST00000352848
O00499
Show all »
Show » Show » 454 50.2 No 0
BIN1-010 ENSP00000259237
ENST00000348750
O00499
Show all »
Show » Show » 409 45.6 No 0
BIN1-011 ENSP00000386797
ENST00000409400
O00499
Show all »
Show » Show » 439 48.3 No 0
BIN1-012 ENSP00000365281
ENST00000376113
O00499
Show all »
Show » Show » 424 47.5 No 0