GYPC

GENE INFORMATION

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Gene name

GYPC (HGNC Symbol)

Synonyms

CD236, CD236R, Ge, GPC, GYPD

Description

glycophorin C (Gerbich blood group) (HGNC Symbol)

Entrez gene summary

Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Chromosome

2 (Chromosome progress)

Cytoband

q14.3

Chromosome location (bp)

127413509 - 127454246

Ensembl

ENSG00000136732 (version 73.37)

Entrez gene

2995

UniProt

P04921 (UniProt - Evidence at protein level)

neXtProt

NX_P04921

Antibodypedia

GYPC antibodies
 

PROTEIN VIEW

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GYPC-001
 
GYPC-002
 
GYPC-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GYPC-001 ENSP00000259254
ENST00000259254
P04921
Show all »
Show » Show » 128 13.8 No 1
GYPC-002 ENSP00000386904
ENST00000409836
P04921
Show all »
Show » Show » 109 11.9 No 1
GYPC-201 ENSP00000349354
ENST00000356887
P04921
Show all »
Show » Show » 107 11.5 No 1