ABI1

GENE INFORMATION

? »

Gene name

ABI1 (HGNC Symbol)

Synonyms

ABI-1, E3B1, SSH3BP1

Description

abl-interactor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]

Chromosome

10 (Chromosome progress)

Cytoband

p12.1

Chromosome location (bp)

27035522 - 27150016

Ensembl

ENSG00000136754 (version 73.37)

Entrez gene

10006

UniProt

Q8IZP0 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IZP0

Antibodypedia

ABI1 antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
ABI1-001
 
ABI1-002
 
ABI1-003
 
ABI1-004
 
ABI1-005
 
ABI1-006
 
ABI1-007
 
ABI1-009
 
ABI1-201
 
ABI1-202
 
ABI1-203
 
ABI1-204
 
ABI1-205
 
ABI1-206
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABI1-001 ENSP00000365308
ENST00000376138
Q8IZP0
Show all »
Show » Show » 452 49.4 No 0
ABI1-002 ENSP00000365340
ENST00000376170
Q8IZP0
Show all »
Show » Show » 451 49.3 No 0
ABI1-003 ENSP00000365336
ENST00000376166
Q8IZP0
Show all »
Show » Show » 446 48.7 No 0
ABI1-004 ENSP00000365330
ENST00000376160
Q8IZP0
Show all »
Show » Show » 475 51.8 No 0
ABI1-005 ENSP00000365312
ENST00000376142
Q8IZP0
Show all »
Show » Show » 508 55.1 No 0
ABI1-006 ENSP00000365310
ENST00000376140
Q8IZP0
Show all »
Show » Show » 481 52.5 No 0
ABI1-007 ENSP00000352114
ENST00000359188
Q8IZP0
Show all »
Show » Show » 480 52.4 No 0
ABI1-009 ENSP00000365309
ENST00000376139
Q8IZP0
Show all »
Show » Show » 476 51.8 No 0
ABI1-201 ENSP00000279599
ENST00000346832
Q8IZP0
Show all »
Show » Show » 496 53.9 No 0
ABI1-202 ENSP00000347555
ENST00000355394
A6NFN2
Show all »
Show » Show » 509 55.3 No 0
ABI1-203 ENSP00000365304
ENST00000376134
F8WA56
Show all »
Show » Show » 482 52.6 No 0
ABI1-204 ENSP00000365307
ENST00000376137
F8WA55
Show all »
Show » Show » 423 46.6 No 0
ABI1-205 ENSP00000440101
ENST00000490841
Q8IZP0
Show all »
Show » Show » 329 35.9 No 0
ABI1-206 ENSP00000439646
ENST00000536334
F5H1G9
Show all »
Show » Show » 394 43.5 No 0