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GENE INFORMATION

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Gene name

TLR4 (HGNC Symbol)

Synonyms

CD284, hToll, TLR-4

Description

toll-like receptor 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

9 (Chromosome progress)

Cytoband

q33.1

Chromosome location (bp)

120466610 - 120479149

Ensembl

ENSG00000136869 (version 69.37)

Entrez gene

7099

UniProt

O00206

neXtProt

NX_O00206

Antibodypedia

TLR4 antibodies
 

PROTEIN VIEW

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TLR4-001
 
TLR4-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TLR4-001 ENSP00000363089
ENST00000355622
O00206
Show all »
Show » Show » 839 95.7 Yes 1
TLR4-002 ENSP00000377997
ENST00000394487
O00206
Show all »
Show » Show » 799 91.3 No 1