ALDOB

GENE INFORMATION

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Gene name

ALDOB

Synonyms

Description

aldolase B, fructose-bisphosphate (HGNC Symbol)

Entrez gene summary

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]

Chromosome

9 (Chromosome progress)

Cytoband

q31.1

Chromosome location (bp)

104182860 - 104198105

Ensembl

ENSG00000136872 (version 73.37)

Entrez gene

229

UniProt

P05062 (UniProt - Evidence at protein level)

neXtProt

NX_P05062

Antibodypedia

ALDOB antibodies
 

PROTEIN VIEW

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ALDOB-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALDOB-001 ENSP00000363988
ENST00000374855
P05062
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