FPGS

GENE INFORMATION

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Gene name

FPGS

Synonyms

Description

folylpolyglutamate synthase (HGNC Symbol)

Entrez gene summary

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

9 (Chromosome progress)

Cytoband

q34.11

Chromosome location (bp)

130556876 - 130576606

Ensembl

ENSG00000136877 (version 73.37)

Entrez gene

2356

UniProt

Q05932 (UniProt - Evidence at protein level)

neXtProt

NX_Q05932

Antibodypedia

FPGS antibodies
 

PROTEIN VIEW

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FPGS-001
 
FPGS-011
 
FPGS-012
 
FPGS-017
 
FPGS-020
 
FPGS-201
 
FPGS-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FPGS-001 ENSP00000406328
ENST00000423577
Q5JU21
Show all »
Show » 194 21.6 No 0
FPGS-011 ENSP00000362344
ENST00000373247
Q05932
Show all »
Show » Show » 587 64.6 Yes 0
FPGS-012 ENSP00000362322
ENST00000373225
Q05932
Show all »
Show » Show » 537 59.2 No 0
FPGS-017 ENSP00000362325
ENST00000373228
Q5JU23
Show all »
Show » 375 40.9 Yes 0
FPGS-020 ENSP00000400007
ENST00000431857
Q5JU20
Show all »
Show » Show » 265 29.2 No 0
FPGS-201 ENSP00000362342
ENST00000373245
Q5JU23
Show all »
Show » 375 40.9 Yes 0
FPGS-202 ENSP00000377309
ENST00000393706
Q05932
Show all »
Show » Show » 561 61.6 Yes 0