IL33

GENERAL INFORMATION

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Gene name

IL33

Gene description

Interleukin 33

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

High and selective nuclear expression in endothelial cells, in a subset of lymphoid cells outside reaction centra and in a fraction of cells in some epithelia.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA024426 , CAB007057
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

IL33 (HGNC Symbol)

Synonyms

C9orf26, DKFZp586H0523, DVS27, IL1F11, NF-HEV

Description

Interleukin 33 (HGNC Symbol)

Entrez gene summary

IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]

Chromosome

9

Cytoband

p24.1

Chromosome location (bp)

6215786 - 6257983

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137033 (version 78.38)

Entrez gene

90865

UniProt

O95760 (UniProt - Evidence at protein level)

neXtProt

NX_O95760

Antibodypedia

IL33 antibodies


PROTEIN BROWSER

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ENST00000381434
 
ENST00000417746
 
ENST00000456383
 
ENST00000611532
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL33-001 ENSP00000370842
ENST00000381434
O95760
Show all »
Show » Show » 270 30.8 No 0
IL33-201 ENSP00000394039
ENST00000417746
O95760
Show all »
Show » Show » 144 16.2 No 0
IL33-202 ENSP00000414238
ENST00000456383
O95760
Show all »
Show » Show » 228 25.9 No 0
IL33-203 ENSP00000478858
ENST00000611532
O95760
Show all »
Show » Show » 228 26.1 No 0