TLN1

GENE INFORMATION

? »

Gene name

TLN1 (HGNC Symbol)

Synonyms

ILWEQ, TLN

Description

talin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

Chromosome

9 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

35696945 - 35732392

Ensembl

ENSG00000137076 (version 73.37)

Entrez gene

7094

UniProt

Q9Y490 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y490

Antibodypedia

TLN1 antibodies
 

PROTEIN VIEW

? »
 
 
 
TLN1-001
 
TLN1-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TLN1-001 ENSP00000316029
ENST00000314888
Q9Y490
Show all »
Show » Show » 2541 269.8 No 0
TLN1-201 ENSP00000442981
ENST00000540444
Q5TCU6
Show all »
Show » 2429 258.1 No 0