PIM1

GENE INFORMATION

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Gene name

PIM1 (HGNC Symbol)

Synonyms

PIM

Description

pim-1 oncogene (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

Chromosome

6 (Chromosome progress)

Cytoband

p21.2

Chromosome location (bp)

37137979 - 37143202

Ensembl

ENSG00000137193 (version 73.37)

Entrez gene

5292

UniProt

P11309 (UniProt - Evidence at protein level)

neXtProt

NX_P11309

Antibodypedia

PIM1 antibodies
 

PROTEIN VIEW

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PIM1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIM1-003 ENSP00000362608
ENST00000373509
P11309
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