IRF4

GENE INFORMATION

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Gene name

IRF4 (HGNC Symbol)

Synonyms

LSIRF, MUM1

Description

interferon regulatory factor 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Chromosome

6 (Chromosome progress)

Cytoband

p25.3

Chromosome location (bp)

391739 - 411447

Ensembl

ENSG00000137265 (version 73.37)

Entrez gene

3662

UniProt

Q15306 (UniProt - Evidence at protein level)

neXtProt

NX_Q15306

Antibodypedia

IRF4 antibodies
 

PROTEIN VIEW

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IRF4-001
 
IRF4-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IRF4-001 ENSP00000370343
ENST00000380956
Q15306
Show all »
Show » Show » 451 51.8 No 0
IRF4-005 ENSP00000436094
ENST00000493114
F2Z3D5
Show all »
Show » Show » 410 46.8 No 0