The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Distinct cytoplasmic and membranous positivity was observed in subsets of cells in cases of squamous cell carcinomas. Remaining malignant cells were generally negative.
Most of the malignant cells displayed moderate membranous positivity often with additional cytoplasmic staining. A few cases of breast, ovarian, colorectal and prostate cancers were strongly stained. Malignant gliomas and lymphomas, embryonal and renal cancers were weakly stained or negative.
Most malignant cells showed weak to moderate positivity. Several cases of pancreatic cancers were strongly stained. Malignant gliomas, lymphomas and melanomas, endometrial, ovarian and colorectal cancers were in general negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
