CLPS

GENE INFORMATION

? »

Gene name

CLPS

Synonyms

Description

colipase, pancreatic (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

6 (Chromosome progress)

Cytoband

p21.31

Chromosome location (bp)

35762759 - 35765088

Ensembl

ENSG00000137392 (version 73.37)

Entrez gene

1208

UniProt

P04118 (UniProt - Evidence at protein level)

neXtProt

NX_P04118

Antibodypedia

CLPS antibodies
 

PROTEIN VIEW

? »
 
 
 
CLPS-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLPS-001 ENSP00000259938
ENST00000259938
P04118
Show all »
Show » Show » 112 12 Yes 0