PRCP

GENERAL INFORMATION

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Gene name

PRCP

Gene description

Prolylcarboxypeptidase (angiotensinase C)

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA017065
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PRCP (HGNC Symbol)

Synonyms

HUMPCP, PCP

Description

Prolylcarboxypeptidase (angiotensinase C) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q14.1

Chromosome location (bp)

82823502 - 82970584

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137509 (version 78.38)

Entrez gene

5547

UniProt

P42785 (UniProt - Evidence at protein level)

neXtProt

NX_P42785

Antibodypedia

PRCP antibodies


PROTEIN BROWSER

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ENST00000313010
 
ENST00000393399
 
ENST00000527444
 
ENST00000528082
 
ENST00000529671
 
ENST00000531128
 
ENST00000531801
 
ENST00000532809
 
ENST00000533126
 
ENST00000534264
 
ENST00000534396
 
ENST00000534631
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRCP-001 ENSP00000317362
ENST00000313010
P42785
Show all »
Show » Show » 496 55.8 Yes 0
PRCP-002 ENSP00000377055
ENST00000393399
P42785
Show all »
Show » Show » 517 58.1 Yes 0
PRCP-005 ENSP00000436141
ENST00000527444
E9PQN3
Show all »
Show » Show » 183 20.5 No 0
PRCP-006 ENSP00000431435
ENST00000531128
E9PL85
Show all »
Show » Show » 148 16.5 No 0
PRCP-007 ENSP00000432004
ENST00000531801
E9PIG4
Show all »
Show » Show » 234 26.4 No 0
PRCP-008 ENSP00000431559
ENST00000534631
E9PKN6
Show all »
Show » Show » 192 21.6 No 0
PRCP-009 ENSP00000431496
ENST00000533126
E9PL49
Show all »
Show » Show » 43 5.1 No 0
PRCP-010 ENSP00000435071
ENST00000528082
E9PLY4
Show all »
Show » Show » 100 11.1 No 0
PRCP-011 ENSP00000434771
ENST00000529671
E9PNJ1
Show all »
Show » Show » 164 18.6 No 0
PRCP-012 ENSP00000437169
ENST00000532809
E9PNF7
Show all »
Show » Show » 116 13.5 No 0
PRCP-013 ENSP00000436095
ENST00000534264
E9PR42
Show all »
Show » Show » 26 3.1 No 0
PRCP-019 ENSP00000432506
ENST00000534396
E9PQB5
Show all »
Show » Show » 145 16.3 No 0