TRPC6

GENE INFORMATION

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Gene name

TRPC6 (HGNC Symbol)

Synonyms

TRP6

Description

transient receptor potential cation channel, subfamily C, member 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]

Chromosome

11 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

101322295 - 101743293

Ensembl

ENSG00000137672 (version 73.37)

Entrez gene

7225

UniProt

Q9Y210 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y210

Antibodypedia

TRPC6 antibodies
 

PROTEIN VIEW

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TRPC6-001
 
TRPC6-002
 
TRPC6-003
 
TRPC6-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRPC6-001 ENSP00000340913
ENST00000344327
Q9Y210
Show all »
Show » Show » 931 106.3 No 8
TRPC6-002 ENSP00000343672
ENST00000348423
Q9Y210
Show all »
Show » Show » 815 93.2 No 7
TRPC6-003 ENSP00000353687
ENST00000360497
Q9Y210
Show all »
Show » Show » 876 100.1 No 7
TRPC6-004 ENSP00000435574
ENST00000532133
E9PJN4
Show all »
Show » Show » 853 97.3 No 7