CASP1

GENE INFORMATION

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Gene name

CASP1 (HGNC Symbol)

Synonyms

ICE, IL1BC

Description

caspase 1, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]

Chromosome

11 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

104896170 - 104972158

Ensembl

ENSG00000137752 (version 73.37)

Entrez gene

834

UniProt

P29466 (UniProt - Evidence at protein level)

neXtProt

NX_P29466

Antibodypedia

CASP1 antibodies
 

PROTEIN VIEW

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CASP1-001
 
CASP1-002
 
CASP1-003
 
CASP1-004
 
CASP1-005
 
CASP1-007
 
CASP1-008
 
CASP1-009
 
CASP1-010
 
CASP1-014
 
CASP1-201
 
CASP1-202
 
CASP1-203
 
CASP1-204
 
CASP1-205
 
CASP1-206
 
CASP1-207
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP1-001 ENSP00000410076
ENST00000436863
P29466
Show all »
Show » Show » 404 45.2 No 0
CASP1-002 ENSP00000433138
ENST00000533400
P29466
Show all »
Show » Show » 404 45.2 No 0
CASP1-003 ENSP00000431947
ENST00000529871
Q5FBZ0
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Show » 110 12.3 No 0
CASP1-004 ENSP00000434779
ENST00000525825
P29466
Show all »
Show » Show » 383 42.9 No 0
CASP1-005 ENSP00000434259
ENST00000528974
B4DVD8
Show all »
Show » 301 33 No 0
CASP1-007 ENSP00000432340
ENST00000527979
G3V169
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Show » 367 40.9 No 0
CASP1-008 ENSP00000436875
ENST00000534497
P29466
Show all »
Show » Show » 263 29.8 No 0
CASP1-009 ENSP00000434250
ENST00000526568
P29466
Show all »
Show » Show » 311 35 No 0
CASP1-010 ENSP00000434303
ENST00000531166
P29466
Show all »
Show » Show » 88 10.4 No 0
CASP1-014 ENSP00000435536
ENST00000532439
H0YEC7
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Show » 236 26.7 No 0
CASP1-201 ENSP00000344132
ENST00000353247
P29466
Show all »
Show » Show » 88 10.4 No 0
CASP1-202 ENSP00000376844
ENST00000393136
P29466
Show all »
Show » Show » 383 42.9 No 0
CASP1-203 ENSP00000408446
ENST00000415981
P29466
Show all »
Show » Show » 88 10.4 No 0
CASP1-204 ENSP00000403260
ENST00000446369
P29466
Show all »
Show » Show » 263 29.8 No 0
CASP1-205 ENSP00000469724
ENST00000593315
P29466
Show all »
Show » Show » 383 42.9 No 0
CASP1-206 ENSP00000472457
ENST00000594519
P29466
Show all »
Show » Show » 263 29.8 No 0
CASP1-207 ENSP00000470811
ENST00000598974
P29466
Show all »
Show » Show » 404 45.2 No 0