CASP5

GENERAL INFORMATION

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Gene name

CASP5

Gene description

Caspase 5, apoptosis-related cysteine peptidase

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (appendix, colon, duodenum, rectum, small intestine)
GTEx:Group enriched (colon, small intestine, spleen)

Protein evidence

Evidence at protein level

Protein localization

General nuclear and cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA040937
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (appendix, colon, duodenum, rectum, small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (colon, small intestine, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

CASP5 (HGNC Symbol)

Synonyms

ICE(rel)III

Description

Caspase 5, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

Chromosome

11

Cytoband

q22.3

Chromosome location (bp)

104994235 - 105023168

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137757 (version 78.38)

Entrez gene

838

UniProt

P51878 (UniProt - Evidence at protein level)

neXtProt

NX_P51878

Antibodypedia

CASP5 antibodies


PROTEIN BROWSER

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ENST00000260315
 
ENST00000393141
 
ENST00000418434
 
ENST00000444749
 
ENST00000456094
 
ENST00000526056
 
ENST00000531367
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP5-001 ENSP00000260315
ENST00000260315
P51878
Show all »
Show » Show » 434 49.7 No 0
CASP5-002 ENSP00000388365
ENST00000444749
P51878
Show all »
Show » Show » 376 43.3 No 0
CASP5-005 ENSP00000415241
ENST00000456094
C9JF14
Show all »
Show » Show » 165 19 No 0
CASP5-006 ENSP00000436877
ENST00000526056
P51878
Show all »
Show » Show » 447 51.2 No 0
CASP5-007 ENSP00000434471
ENST00000531367
P51878
Show all »
Show » Show » 292 33.3 No 0
CASP5-201 ENSP00000376849
ENST00000393141
P51878
Show all »
Show » Show » 447 51.2 No 0
CASP5-202 ENSP00000398130
ENST00000418434
P51878
Show all »
Show » Show » 292 33.3 No 0