CASP5

GENE INFORMATION

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Gene name

CASP5 (HGNC Symbol)

Synonyms

ICE(rel)III

Description

caspase 5, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

Chromosome

11 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

104864962 - 104893895

Ensembl

ENSG00000137757 (version 73.37)

Entrez gene

838

UniProt

P51878 (UniProt - Evidence at transcript level)

neXtProt

NX_P51878

Antibodypedia

CASP5 antibodies
 

PROTEIN VIEW

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CASP5-001
 
CASP5-002
 
CASP5-003
 
CASP5-004
 
CASP5-005
 
CASP5-006
 
CASP5-007
 
CASP5-201
 
CASP5-202
 
CASP5-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP5-001 ENSP00000260315
ENST00000260315
P51878
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Show » Show » 434 49.7 No 0
CASP5-002 ENSP00000388365
ENST00000444749
P51878
Show all »
Show » Show » 376 43.3 No 0
CASP5-003 ENSP00000408455
ENST00000456200
P51878
Show all »
Show » Show » 108 12.7 No 0
CASP5-004 ENSP00000396053
ENST00000438448
Show » 117 13.3 No 0
CASP5-005 ENSP00000415241
ENST00000456094
C9JF14
Show all »
Show » 165 19 No 0
CASP5-006 ENSP00000436877
ENST00000526056
P51878
Show all »
Show » Show » 447 51.2 No 0
CASP5-007 ENSP00000434471
ENST00000531367
P51878
Show all »
Show » Show » 292 33.3 No 0
CASP5-201 ENSP00000376847
ENST00000393139
A8MZ63
Show all »
Show » 133 15.4 No 0
CASP5-202 ENSP00000376849
ENST00000393141
P51878
Show all »
Show » Show » 447 51.2 No 0
CASP5-203 ENSP00000398130
ENST00000418434
P51878
Show all »
Show » Show » 292 33.3 No 0