MAP2K5

GENE INFORMATION

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Gene name

MAP2K5 (HGNC Symbol)

Synonyms

HsT17454, MAPKK5, MEK5, PRKMK5

Description

mitogen-activated protein kinase kinase 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

Chromosome

15 (Chromosome progress)

Cytoband

q23

Chromosome location (bp)

67835047 - 68099461

Ensembl

ENSG00000137764 (version 73.37)

Entrez gene

5607

UniProt

Q13163 (UniProt - Evidence at protein level)

neXtProt

NX_Q13163

Antibodypedia

MAP2K5 antibodies
 

PROTEIN VIEW

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MAP2K5-001
 
MAP2K5-002
 
MAP2K5-003
 
MAP2K5-005
 
MAP2K5-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP2K5-001 ENSP00000178640
ENST00000178640
Q13163
Show all »
Show » Show » 448 50.1 No 0
MAP2K5-002 ENSP00000342101
ENST00000340972
A6NK28
Show all »
Show » 258 29.2 No 0
MAP2K5-003 ENSP00000390196
ENST00000439036
H7BZL1
Show all »
Show » 128 14.1 No 0
MAP2K5-005 ENSP00000346493
ENST00000354498
Q13163
Show all »
Show » Show » 412 46.1 No 0
MAP2K5-013 ENSP00000378859
ENST00000395476
Q13163
Show all »
Show » Show » 438 49 No 0