THBS1

GENERAL INFORMATION

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Gene name

THBS1

Gene description

Thrombospondin 1

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (appendix)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic and membranous expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Data reliability

Uncertain based on 1 antibody.
CAB033678
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Appendix

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (appendix)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

THBS1 (HGNC Symbol)

Synonyms

THBS, THBS-1, TSP, TSP-1, TSP1

Description

Thrombospondin 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q14

Chromosome location (bp)

39581079 - 39599466

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137801 (version 78.38)

Entrez gene

7057

UniProt

P07996 (UniProt - Evidence at protein level)

neXtProt

NX_P07996

Antibodypedia

THBS1 antibodies


PROTEIN BROWSER

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ENST00000260356
 
ENST00000397591
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

THBS1-001 ENSP00000260356
ENST00000260356
P07996
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Show » Show » 1170 129.4 Yes 0
THBS1-002 ENSP00000380720
ENST00000397591
A8MZG1
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Show » Show » 94 10.1 Yes 0