CASC5

GENERAL INFORMATION

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Gene name

CASC5

Gene description

Cancer susceptibility candidate 5

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in several tissues, most abundant in testis.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA026624
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

CASC5 (HGNC Symbol)

Synonyms

AF15Q14, CT29, D40, hKNL-1, hSpc105, KNL1, PPP1R55, Spc7

Description

Cancer susceptibility candidate 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]

Chromosome

15

Cytoband

q15.1

Chromosome location (bp)

40594020 - 40664342

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137812 (version 78.38)

Entrez gene

57082

UniProt

Q8NG31 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NG31

Antibodypedia

CASC5 antibodies


PROTEIN BROWSER

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ENST00000346991
 
ENST00000399668
 
ENST00000527044
 
ENST00000528975
 
ENST00000532056
 
ENST00000532406
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASC5-001 ENSP00000382576
ENST00000399668
Q8NG31
Show all »
Show » Show » 2316 262.6 No 0
CASC5-002 ENSP00000335463
ENST00000346991
Q8NG31
Show all »
Show » Show » 2342 265.4 No 0
CASC5-005 ENSP00000454087
ENST00000528975
Show » 7 0.9 No 0
CASC5-006 ENSP00000454002
ENST00000532056
Show » 10 1.3 No 0
CASC5-008 ENSP00000436851
ENST00000532406
Show » 193 22.3 No 0
CASC5-201 ENSP00000432654
ENST00000527044
Show » 1746 195.6 No 0