RPLP1

GENE INFORMATION

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Gene name

RPLP1 (HGNC Symbol)

Synonyms

LP1

Description

ribosomal protein, large, P1 (HGNC Symbol)

Entrez gene summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

15 (Chromosome progress)

Cytoband

q23

Chromosome location (bp)

69745123 - 69748255

Ensembl

ENSG00000137818 (version 73.37)

Entrez gene

6176

UniProt

P05386 (UniProt - Evidence at protein level)

neXtProt

NX_P05386

Antibodypedia

RPLP1 antibodies
 

PROTEIN VIEW

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RPLP1-001
 
RPLP1-002
 
RPLP1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPLP1-001 ENSP00000346037
ENST00000260379
P05386
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Show » Show » 114 11.5 No 0
RPLP1-002 ENSP00000350437
ENST00000357790
P05386
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Show » Show » 89 8.8 No 0
RPLP1-006 ENSP00000453067
ENST00000560274
H0YL57
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Show » 54 6.4 No 0