DUOX1

GENERAL INFORMATION

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Gene name

DUOX1

Gene description

Dual oxidase 1

Protein class

Enzymes
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

Membrane,Secreted

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (esophagus, skin, thyroid gland)
GTEx:Tissue enhanced (thyroid gland)

Protein evidence

Evidence at protein level

Protein localization

Strong cytoplasmic staining was seen in urothelium, gall bladder, endocrine cells in intestine and gastric parietal cells. The thyroid gland, ovarian follicles and subsets of neuronal cells showed moderate positivity. Remaining normal cells were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA023544
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (esophagus, skin, thyroid gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (thyroid gland)

Organ

Expression



GENE INFORMATION

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Gene name

DUOX1 (HGNC Symbol)

Synonyms

LNOX1, NOXEF1, THOX1

Description

Dual oxidase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

Chromosome

15

Cytoband

q21.1

Chromosome location (bp)

45129933 - 45165576

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137857 (version 78.38)

Entrez gene

53905

UniProt

Q9NRD9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NRD9

Antibodypedia

DUOX1 antibodies


PROTEIN BROWSER

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ENST00000321429
 
ENST00000389037
 
ENST00000558322
 
ENST00000561166
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUOX1-001 ENSP00000373689
ENST00000389037
Q9NRD9
Show all »
Show » Show » 1551 177.2 Yes 7
DUOX1-005 ENSP00000454065
ENST00000561166
Q9NRD9
Show all »
Show » Show » 1197 137.6 Yes 7
DUOX1-006 ENSP00000317997
ENST00000321429
Q9NRD9
Show all »
Show » Show » 1551 177.2 Yes 7
DUOX1-007 ENSP00000454121
ENST00000558322
H0YNR5
Show all »
Show » 43 5 Yes 0