DUOX1

GENE INFORMATION

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Gene name

DUOX1 (HGNC Symbol)

Synonyms

LNOX1, NOXEF1, THOX1

Description

dual oxidase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

Chromosome

15 (Chromosome progress)

Cytoband

q21.1

Chromosome location (bp)

45422131 - 45457774

Ensembl

ENSG00000137857 (version 73.37)

Entrez gene

53905

UniProt

Q9NRD9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NRD9

Antibodypedia

DUOX1 antibodies
 

PROTEIN VIEW

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DUOX1-001
 
DUOX1-003
 
DUOX1-005
 
DUOX1-006
 
DUOX1-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUOX1-001 ENSP00000373689
ENST00000389037
Q9NRD9
Show all »
Show » Show » 1551 177.2 Yes 7
DUOX1-003 ENSP00000452623
ENST00000561220
H0YK19
Show all »
Show » 444 49.5 Yes 0
DUOX1-005 ENSP00000454065
ENST00000561166
Q9NRD9
Show all »
Show » Show » 1197 137.6 Yes 7
DUOX1-006 ENSP00000317997
ENST00000321429
Q9NRD9
Show all »
Show » Show » 1551 177.2 Yes 7
DUOX1-007 ENSP00000454121
ENST00000558322
H0YNR5
Show all »
Show » Show » 43 5 Yes 0